Optics in Biology and Medicine, Vision and Color, and Optical Sciences Package
Please note: Final session recording schedule is subject to onsite changes and speaker permission.
Monday 17 October 2011
Special Symposium on Integrated Optofluidics for the Life Sciences
FMA1 - Optofluidic Manipulation Of Particles For Separation, Purification, and Analysis, Sean Hart, Intel Capital, United States
An optofluidic system and applications are described where biological samples are characterized and separated in a microfluidic device based upon their intrinsic properties. As an example, optical force differences have been measured between various human
FMA2 - Single-Molecule Biophysics with Optofluidic Trapping, David Erickson, Cornell University, United States
I will present our recent work on the optical trapping and manipulation of single molecules and nanomaterials using the near-field of integrated photonic devices.
FMA3 - Integration Methods for Raman spectroscopy and Passive Sorting in Optofluidics, Praveen Ashok, University of St Andrews, United Kingdom
Applications of Waveguide Confined Raman Spectroscopy (WCRS) which realizes an alignment-free microfluidic chip for Raman spectroscopic detection of analytes is described. Separately passive optical sorting techniques in optofluidics are discussed.
FMA4 - Optofluidic Tomography, Serhan Isikman, UCLA, United States
We demonstrate an optofluidic tomographic microscope on a chip. Lensfree holograms of objects flowing through a microfluidic-channel are recorded at multiple illumination angles to compute sub-pixel resolved tomograms for 3D imaging on a chip.
FMA5 - Compact and Cost-effective Lensfree Reflection and Transmission Microscopy on Chip, Aydogan Ozcan, UCLA, United States
We present a field-portable lensfree dual-mode (i.e., reflection and transmission on-chip microscope that can digitally image e.g., blood cells and dense histopathology slides, providing a lateral resolution of ~2µm over a wide field-of-view.
Special Symposium on Integrated Optofluidics for the Life Sciences II
FMH1 - Chip Integrated Optical Manipulation of Single Airborne Particles, Marcel Horstmann, Institute of Applied Physics, Westfälische Wilhelms-Universität, Germany
An integrated system for the optical manipulation and characterization of single airborne microparticles is presented. Optical fibers are used to deliver the trapping laser light as well as to collect scattered light for Raman spectroscopy.
FMH2 - Holographic Control and High-Speed Imaging for Studies of Hydrodynamic Coupling on A Micron Scale, Miles Padgett, University of Glasgow, United Kingdom
New interfaces make holographic optical tweezers an attractive tool within many branches of science. Here we use optical tweezers in the study of hydrodynamic interactions, specifically the hydrodynamic synchronization of thermally driven bi-stable systems.
FMH3 - Label-free Cytometry via Wavefront Sensing, James Jacob, CytoRay, Actinix, United States
We describe a new label-free technique to analyze cells. A wavefront sensor measures the aberrations imparted onto a laser beam by single cells. The calculated Zernike coefficients of the deformed wavefronts comprise unique cellular signatures.
FMH5 - Adaptive Nanodispenser Microrobot for Lab-On-A-Chip in Microfluidic Platform, Pietro Ferraro, Istituto Nazionale di Ottica, Italy
A novel and interesting approach of electrode-less technique to grip and transport micro objects driven by pyroelectric effect is demonstrated. The force is generated by applying thermal stimulus on Lithium Niobate crystal by an IR laser.
FMH6 - Thermal Manipulation of Water Droplets - A Path to Droplet Microfluidics, Gregory Faris, SRI International, United States
Optical manipulation of water droplets in an oil matrix is important in the development of droplet microfluidics. In this report we demonstrate infrared laser based droplet manipulation using the thermal Marangoni effect and thermal convection.
Fluorescence and Other Imaging Techniques
FML1 - In Vivo Imaging of Tumors Using Multiphoton Fluorescence and Second Harmonic Generation, Ed Brown, Univ. of Rochester, United States
In this tutorial we will discuss how epifluorescence microscopy, confocal laser-scanning microscopy, and multiphoton laser-scanning microscopy are used to provide a detailed understanding of the pathophysiology of living tumors.
FML2 - Second-Harmonic Microscopy for Cornea Collagen Fibril Imaging: Theoretical and Experimental Optimization, Brian Vohnsen, University College Dublin, Ireland
Second-harmonic microscopy for collagen fibril imaging in the post-mortem porcine cornea has been analyzed experimentally and theoretically in order to optimize 3-D imaging while reducing light toxicity towards in-vivo applications.
FML3 - Imaging Spectroscopy Without a Spectrometer, Thomas Kohlgraf-Owens, CREOL, The College of Optics and Photonics, University of Central Florida, United States
Imaging spectroscopy implies a trade-off between spectral, spatial, and temporal resolution. We present a technique that allows for dynamic adjustment of the spectral-spatial trade-off with snapshot measurements.
FML4 - In Vivo Particle Bombardment and Viral Methods for Specific Cellular and Subcellular Labeling, Ken Greenberg, Spiral Genomics LLC,
We demonstrate bright coherent X-ray supercontinua generated through fully phase-matched upconversion of mid-IR laser light into the keV spectral region. The ultrabroad bandwidths can support pulse durations of few attoseconds, scalable to zeptosecond time scales.
FML5 - How to Enhance the Two-Photon Brightness of Fluorescent Proteins?, Mikhail Drobizhev, Montana State University, United States
Fluorescent proteins (FPs) are widely used in two-photon laser microscopy as genetically-targeted probes. We provide the guidelines for increasing their peak 2PA cross section by tuning (via mutations) local electric field inside protein.
FML6 - Spectrally Encoded Imaging, Dongkyun Kang, Massachusetts General Hospital and Harvard Medical School, United States
Spectrally encoded imaging is a high-speed endoscopic imaging technology that encodes a transverse coordinate of the sample in the wavelength. We will discuss spectrally encoded confocal microscopy and spectrally encoded endoscopy.
Tuesday 18 October 2011
Optofluidics for Enhanced Sensing
FTuJ1 - Optofluidic Nanostructures for Concentration and Sensing, David Sinton, University of Victoria, Canada
We demonstrate the first active utilization of flow-through nanohole array sensors for achieving both the active electrohydrodynamic concentration and the subsequent sensing of electrically charged analyte using the same optofluidic nanostructure.
FTuJ2 - Title to be Announced, Michal Lipson, Cornell University, United States
Abstract not available.
FTuJ3 - Determination of Microdroplet Contact Angles Using Electrically Eriven Droplet Oscillations, Yasin Karadag, Koç Universty, Turkey
Contact angles of micrometer-sized NaCl-water droplets are determined by whispering gallery mode spectroscopy, using the dependence of the lowest-order mechanical resonant frequency of the electrically driven droplet oscillations on the droplet size.
FTuJ4 - Enhancing the Sensitivity of Whispering Gallery Mode Biosensors Using Plasmons, Jon Swaim, University of Queensland, Australia
We show that a localized surface plasmon resonance in a metallic nanorod can reduce the optical mode volume of a whispering gallery mode resonator by as much as 30000, significantly improving its detection sensitivity as a biological sensor.
Lasers and Photoemission for Accelerator Science
FTuR1 - Lasers for High Brightness X-Fel Photo Injectors, William White, , United States
Performance of the LCLS x-ray FEL is critically dependent on characteristics of a conventional laser that drives the RF-photogun, generating a high-brightness electron beam. The evolution and future of this laser system will be discussed.
FTuR2 - High-energy Femtosecond Laser Sources at MHz Repetition Rates for Experiments with Picosecond-/Femtosecond-/Attosecond Electron Bunches, Alexander Apolonski, MPQ, Ludwig-Maximilians-Universitaet Muenchen, Germany
Several high-energy femtosecond laser systems at MHz repetition rates developed in our group together with their scientific applications are described.
FTuR3 - Ultrafast, Plasmonically Enhanced Photoemission from Metals, Péter Dombi, Research Institute for Solid-State Physics and Optics, Hungary
Ultrafast plasmonic phenomena are increasingly important related to the field enhancement and sub-wavelength confinement of plasmons. We review few-cycle plasmon generation, strong-field plasmonic photoemission and all-optical electron acceleration.
FTuR4 - Spectral Control of Supercontinuum Generated by Intense Femtosecond Pulses with Diffractive Optics, Rocio Borrego Varillas, Universidad de Salamanca, Spain
We demonstrate that supercontinuum generation with a diffractive lens in a sapphire plate gives rise to new spectral phenomenology. Applicability of these pulses is supported by a spatial and temporal study.
Wednesday 19 October 2011
Frequency Combs-I-Sources
FWB1 - Silicon-Chip-Based Optical Frequency Combs, Alexander Gaeta, Cornell University, United States
We describe recent work on the development of chip-based frequency combs based on parametric mixing that offer the promise of highly compact, robust sources for metrology, spectroscopy, and ultrafast applications.
FWB2 - Chip-based Frequency Comb with Microwave Repetition Rate, Jiang Li, California Institutute of Technology, United States
A silicon-chip microcomb accessing the important microwave-rate FSR range is reported. 22.9 and 33.2 GHz comb spacing devices are demonstrated having 200 comb lines, 200 Hz comb heterodyne beat and threshold as low as 2.3 mW.
FWB3 - Dual-Comb-Based Characterization of Rapidly Tuned Lasers, Fabrizio Giorgetta, National institute of standards and technology, United States
We demonstrate a technique to calibrate the instantaneous frequency versus time from a rapidly tuned cw laser. Our dual-comb-based spectrometer can measure optical waveforms tuned at 1500-THz/s rates over 5-THz bandwidths at high precision.
FWB4 - Hybrid 2-µm Er:Fiber/Tm:Fiber Frequency Comb, Florian Adler, National Institute of Standards and Technology, University of Colorado, United States
We present a 2-µm frequency comb based on a spectrally broadened mode-locked Er:fiber laser. A single-clad Tm/Ho:fiber is used as a self-pumped pre-amplifier, a double-clad Tm:fiber amplifier boosts the system to high output power.
FWB5 - Spectral Broadening of Femtosecond Mid-IR Pulses Coupled into Quantum Cascade Lasers, Sheng Liu, UMBC, UMBC, United States
Femtosecond 4.72 μm Mid-IR pulses are coupled into a pulsed biased, room temperature 4.72 μm QCL, resulting in 2X spectra broadening of the input pulses.
Electron Dynamics in Intense Fields
FWI1 - Attosecond Control of Collective Electron Dynamics in Plasmas, Rodrigo Lopez Martens, CNRS - ENSTA ParisTech - Ecole Polytechnique, France
We demonstrate for the first time attosecond time scale control of collective electron motion in overdense plasmas driven by waveform-controlled few-cycle laser pulses.
FWI2 - Optical Characterization of Laser-Driven Electron Acceleration, Malte Kaluza, Friedrich-Schiller-Universität, Helmholtz-Institute Jena, Germany
We present the first well-resolved experimental observation of the non-linear formation of a laser-driven plasma wave, its breaking leading to self-injection and acceleration of electrons in the wave's electric field in the regime of “Bubble-acceleration”.
FWI3 - Tunable Laser-Driven Electron Acceleration via Shock Front Injection, Alexander Buck, Max Planck Institute of Quantum Optics, Ludwig-Maximilians-Universität, Germany
Stable, relativistic electron beams with up to 100 pC peak charge have been accelerated via injection into wakefields at a sharp density transition. The energy of the accelerator was tunable between 10 and 150 MeV.
FWI4 - Ultrafast X-ray Absorption Spectroscopy of Isochorically Heated Copper Plasmas at Solid Density, Byoung-ick Cho, Lawrence Berkeley Natl Lab, United States
Using ultrafast x-ray technique, we observed the changes of electronic structure of isochorically heated copper. It allows us to determine electron temperature at a few eV regimes and investigate thermo-physical properties of solid-density plasmas.
Looking into the Eyes of Animal Models of Disease
FWO1 - The Guinea Pig as a Model of Myopia, Sally McFadden, University of Newcastle, Australia
An animal model which explores the underlying basis of myopia will be described together with new optical treatments and findings suggesting that the optics of the eye are modified by blur experienced during development.
FWO3 - High Resolution Imaging of the Living Mouse Eye: A Model for Retinal Diseases, Ying Geng, University of Rochester, University of Rochester, United States
A Shack-Hartmann wavefront sensor with an adjustable focus beacon is incorporated into a fluorescence adaptive optics scanning laser ophthalmoscope. The instrument delivers high resolution images of multiple cell mosaics in the living mouse eye.
FWO4 - Wavefront Tomography of the Human Eye Assisted with Corneal Topography and Optical Path Measurements, Chris Dainty, National University of Ireland Galway, Ireland
We present a new method of reconstructing the optical system of the eye based on combined data from an aberrometer, corneal topographer and a partial coherence interferometer (IOL Master), which is used for customized eye model optimization.
FWO5 - Probing Global Aging Changes to Photoreceptors, Ann Elsner, Indiana University/Aeon Imaging, United States
Global changes with age in the density of photoreceptors were investigated by using novel software to compute the thickness of the outer nuclear layer seen with Optical Coherence Tomography.
FWO6 - Visual Performance of the Human Eye - Combining Optical modeling and Square Root Integral Method, Krishnakumar Venkateswaran, Alcon Laboratories, Inc, United States
In this paper we present the results of a model to predict clinical performance by combining optical MTF of a human eye and mathematical model of contrast sensitivity.
High Fields and Plasmas
FWP1 - Application of a Multi-Terawatt 3ps CO2 Laser for Monoenergetic Proton Beam Generation, Dan Haberberger, UCLA, United States
15TW picosecond 10μm laser pulses are obtained at the UCLA Neptune laboratory achieving record CO2 laser power. This laser system is applied for laser driven ion acceleration achieving 20 MeV proton beams from a H2 gas jet.
FWP2 - Development of a 0.5 PW high contrast Ti:Sapphire laser system at OSU to achieve peak focal intensities exceeding 1022 W/cm2, Patrick Poole, The Ohio State University, United States
A 0.5 PW 15 J/pulse, 30 fs, 1 shot/min, Ti:Sapphire based high pulse contrast laser system is being constructed at OSU. The laser peak intensity will be measured with a proton acceleration based technic.
FWP3 - Ultra- High Pulse Intensity Amplification and Compression in Plasma, Szymon Suckewer, Princeton University, United States
This talk provides the summary of experimental research at Princeton on Raman Backscattering (RBS) amplification and compression in plasma [1]. The main subject of the talk is about obtaining high efficiency of such system [2,3].
FWP4 - Manipulation of the Laser Properties through Guiding in Plasma Channels, J. van Tilborg, Lawrence Berkeley National Laboratory, United States
Plasma channels allow for guiding of intense laser pulses over many Rayleigh lengths, enhancing laser-plasma interaction. Theory and experimental results are presented on laser properties during guiding such as mode, dispersion, and group velocity.
FWP5 - Modelling Intense Laser Plasma Processes - Bridging the Gap Between Microscopic and Macroscopic Phenomena, Charles Varin, Université d'Ottawa, Canada
To bridge the gap between microscopic particle interactions and macroscopic optical waves propagation, we developed a new numerical tool. First laser-cluster simulations reveal new optical phenomena not accessible by any other existing method.
FWP6 - Seeded Femtosecond Supercontinua in Various Media, David Hagan, University of Central Florida, United States
We investigate enhancement of femtosecond supercontinua (SC) in various nonlinear media including solvents by seeding the SC with nanojoule to microjoule visible pulses. Increasing enhancement for decreasing nonlinear refraction is observed.
Thursday 20 October 2011
Laser-Based Radiation Therapy and Enabling Sources
FThB1 - Prospects for Laser-Driven Ion Beam Therapy, T. Cowan, AFFILIATION NOT AVAILABLE, Germany
Abstract not available.
FThB2 - Laser Plasma Accelerators for Cancer Treatment, Victor Malka, ENSTA, X, CNRS, France
Laser plasma accelerators have made considerable progresses, which make them a future good candidate for medical applications such as radiotherapy or radiobiology.
FThB3 - Providing Thin-Disk Technology for High Laser Pulse Energy at High Average Power, Robert Jung, Max Born Institute, Germany
Thin disk technology has the potential for providing laser pulses with high pulse energy and high repetition rate. Large laser projects like ELI or HiPER benefit from this technology as well as stand alone systems like e.g. laser driven x-ray sources.
FThB4 - Comparative Study on the Temperature Dependent Emission Cross Section of Nd:YAG, Nd:YVO4, and Nd:GdVO4, Yoichi Sato, Institute for Molecular Science, Japan
It was found that the temperature dependence of stimulated emission cross section (σem) of Nd:YVO4 and Nd:GdVO4 were severer than Nd:YAG. σem of Nd:YAG, Nd:YVO4, and Nd:GdVO4 decreased 0.20%/degC, 0.50%/degC, and 0.48%/degC at 20degC, respectively.
Frequency Combs-II-Applications
FThH3 - Absolute Distance Measurement Using Long-Path Heterodyne Interferometer with Optical Frequency Comb, Xiaonan Wang, The University of Tokyo, Japan
A new heterodyne interference system with an acoustic-optical modulator and a piezo-electric transducer is presented to realize absolute long-distance measurement. The experimental results at 22.5m show the reproducibility of 2μm in an hour.
FThH4 - Mid-IR Frequency Combs: Transforming Molecular Spectroscopy as we know it, Evgeni Sorokin, Vienna University of Technology, Germany
The availability of frequency comb sources in the mid-IR is set to change dramatically the way of molecular spectroscopy, suggesting novel measurement techniques but also changing how the conventional devices are being designed and used.
FThH5 - Theory of Molecular Cooling Using Optical Frequency Combs in the Presence of Decoherence, Svetlana Malinovskaya, Stevens institute of Technology, United States
A semiclassical theory demonstrates that a single, phase modulated optical frequency comb may be used to control dynamics in ultracold gases aiming at creation of deeply bound ultracold molecules from Feshbach states.
FThH6 - Interferometric Estimation of the Offset-Frequency of Optical Frequency Comb, Hirokazu Matsumoto, The University of Tokyo, Japan
The carrier-envelop offset frequency of optical frequency comb is evaluated by using a conventional interferometer with an acoustic optical-frequency shifter for establishing practical absolute distance metrology within an accuracy of 2 MHz.
PLUS!
Sunday 16 October 2011
- What’s Hot in Bio-Medical Optics, Adam P. Wax, Duke University, United States
- What’s Hot in Fabrication, Design and Instrumentation, Guoqiang Li, University of Missouri, Saint Louis, USA
- What’s Hot in Information Acquisition, Processing and Display, David Brady, Duke University, United States*
- What’s Hot in Photonics and Opto-Electronics, Juerg Leuthold, Karlsruhe Institute of Technology, Germany*
- What’s Hot in Vision and Color, Joseph Carroll, Medical College of Wisconsin, United States
- What’s Hot in Mid-Infrared Laser Technology: Highlights and Applications, Irina Sorokina, Norwegian Univ. of Science & Technology, Norway*
Monday 17 October 2011
- Lightwave Modulators: Early Days, Ivan Kaminow, University of California Berkeley, United States
- Table-Top Soft X-Ray Lasers: Bright Coherent Light for the Nanoworld, Jorge Rocca, Colorado State University, United States
- Seeing is Believing: Capturing Electrons in Real Time, Ferenc Krausz, Max-Planck-Institut für Quantenoptik & Ludwig-Maximilians-Universität München, Germany
- Inside the Wavelength-Seeing Really Small Objects with Light, John Pendry, The Blackett Lab, Imperial College, United Kingdom
*Pending Author Approval